RT January 26 2014
Scientists have discovered a way to study the causes of Alzheimer disease using a simple single-celled amoeba, which leads to a better understanding of how human proteins mutate. It circumvents the need for animal testing.
British scientists point to the possibility of amoeba use in biomedical studies of the presenilin protein that plays a part in causing Alzheimer disease, widespread among the elderly. A press release about the study by researchers from the Royal Holloway University of London and the Institute of Psychiatry of King’s College, London, was published in the Journal of Cell Science on Friday.
It reveals that the so-called ‘social’ amoeba has become an essential source in the understanding of how human proteins function, whose mutations are associated with the development of dementia. It could lead to the creation of a new generation of treatments for this incurable disease.
Professor Robin Williams, a scientist from Royal Holloway, University of London elaborates on the idea of using amoeba in medical research of epilepsy, saying, “This discovery allows us to examine the role for the human presenilin 1 protein, without the use of animal testing. It is amazing that so simple an organism lends itself to the study of such a complex disease”.